Glucovance Tablet​ 250mg/1.25mg

Description

Glucovance 250mg/1.25mg Tablet: Combined Power for Type 2 Diabetes Management

Glucovance 250mg/1.25mg Tablets combine two effective antidiabetic medications, Glyburide (250mg) and Metformin Hydrochloride (1.25mg), to provide a comprehensive approach to blood sugar control in adults with type 2 diabetes mellitus. This combination therapy targets different aspects of glucose regulation, offering enhanced glycemic control compared to using either medication alone.

• Glyburide: A sulfonylurea that stimulates the beta cells in the pancreas to release more insulin. Insulin is a hormone that helps the body’s cells absorb glucose from the bloodstream, thus lowering blood sugar levels.
• Metformin Hydrochloride: A biguanide that works primarily by reducing the amount of glucose produced by the liver. It also improves insulin sensitivity in the body’s tissues, allowing cells to utilize glucose more effectively.

What are the indications for Glucovance?

Glucovance is indicated for the treatment of type 2 diabetes mellitus in adults to improve glycemic control, particularly when:

• Diet and exercise alone are not enough to manage blood sugar levels.
• Treatment with either Glyburide or Metformin alone has not provided adequate control.
• A combination of both medications is deemed appropriate by a physician.

Glucovance helps to:

• Lower Blood Sugar Levels: Effectively reduces both fasting and postprandial (after-meal) blood glucose levels.
• Improve HbA1c: Lowers HbA1c, a measure of average blood sugar control over the past 2-3 months.
• Address Multiple Aspects of Glucose Regulation: Combines the insulin-stimulating action of Glyburide with the liver glucose-reducing and insulin-sensitizing effects of Metformin.

Can Glucovance cause hypoglycemia?

Yes, Glucovance can cause hypoglycemia (low blood sugar), especially due to the Glyburide component. Sulfonylureas like Glyburide stimulate insulin release regardless of blood sugar levels, increasing the risk of hypoglycemia if meals are skipped, delayed, or if the dosage is too high.

Symptoms of hypoglycemia may include:

• Shakiness
• Sweating
• Dizziness
• Confusion
• Hunger
• Irritability
• Rapid heartbeat
• Headache

It’s important to be aware of these symptoms and know how to treat hypoglycemia (e.g., by consuming a fast-acting source of carbohydrates). Your doctor will provide guidance on managing low blood sugar.

When is the best time to take glyburide metformin? Glucovance before or after meal:

Glucovance (Glyburide/Metformin) is typically taken with meals.

• Best Time: Usually taken once or twice daily with breakfast and/or dinner. Taking it with food helps to reduce the gastrointestinal side effects associated with Metformin.
• Doctor’s Instructions: Your doctor will provide specific instructions on when and how to take the medication based on your individual needs. Always follow your doctor’s advice.

What is the benefit of Glucovance Tablet?

The benefits of Glucovance include:

• Improved Glycemic Control: Effectively lowers blood sugar levels and HbA1c in people with type 2 diabetes.
• Combination Therapy: Addresses multiple aspects of glucose regulation by combining the mechanisms of Glyburide and Metformin.
• Convenience: Combines two medications into a single tablet, potentially improving adherence.
• May Help Reduce the Risk of Long-Term Complications: By improving blood sugar control, it can help reduce the risk of long-term complications of diabetes, such as cardiovascular disease, nerve damage, kidney damage, and eye problems.

Is glyburide safe for kidneys?

Glyburide itself is not primarily eliminated by the kidneys. However, Metformin, the other component of Glucovance, is primarily eliminated by the kidneys.

• Kidney Function: Your doctor will need to assess your kidney function before starting you on Glucovance and should monitor it periodically.
• Kidney Impairment: Glucovance or metformin-containing medicines are generally not recommended for individuals with significant kidney impairment due to the increased risk of lactic acidosis (a rare but serious side effect associated with Metformin).
• Dose Adjustments: Dose adjustments may be needed if you have mild to moderate kidney problems.

Always inform your doctor about any kidney problems you have before taking Glucovance.

Glucovance tablet side effects:

Common side effects of Glucovance may include:

• Hypoglycemia (Low Blood Sugar): More likely due to the Glyburide component.
• Gastrointestinal: Nausea, vomiting, diarrhea, stomach pain, gas, loss of appetite, metallic taste in the mouth.
• Headache
• Weight gain
• Skin rash

Serious side effects are rare but can occur. These may include:

• Lactic Acidosis: A rare but serious buildup of lactic acid in the blood, primarily associated with Metformin, especially in individuals with impaired kidney function. Symptoms include muscle pain, weakness, difficulty breathing, and stomach discomfort. Seek immediate medical attention if you experience these symptoms.
• Severe Hypoglycemia: Can lead to loss of consciousness or seizures.
• Allergic Reactions: Rash, itching, swelling, difficulty breathing.
• Liver problems: Although rare, it can cause liver problems.

Report any unusual or severe side effects to your doctor immediately.

Important Considerations:

• Prescription Medication: Glucovance is a prescription medication and should only be taken under the guidance of a healthcare professional.
• Regular Monitoring: Your doctor will likely monitor your blood sugar levels and kidney function regularly while you are taking Glucovance.
• Interactions: Inform your doctor about all other medications you are taking, as Glucovance can interact with certain drugs.
• Pregnancy and Breastfeeding: Discuss the risks and benefits with your doctor if you are pregnant or breastfeeding.
• Alcohol: Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis and hypoglycemia.

Glucovance tablet dosage:

The dosage of Glucovance is individualized and determined by your doctor. The usual starting dose is 1.25mg/250mg once or twice a day with meals. The dose is adjusted according to the response.

Price:

• Glucovance tablet price in Pakistan: Rs. 92.00 (Please note that this price might be for a specific pack size or strength. Check with your local pharmacy for accurate pricing.)

Consult with your doctor for proper diagnosis and treatment before using Glucovance 250mg/1.25mg Tablets.